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It is mostly used domestically for cigarette production but also finds its way into some shisha tobacco blends." Macedonian tobacco is a major Oriental, as noted in an abstract from Tobacco Prevention and Cessation from the 8th ENSP European Conference on Tobacco Control: "Macedonia is the second largest producer of Oriental leaf worldwide, just behind Turkey." Orientals as a whole are a tricky tobacco family to pin down due to the socio-political situation in the region of Macedonia, Turkey, and other Balkan countries

It contains over 7,000 chemicals, at least 70 of which are proven carcinogens

There are at least 1,987 strains of marijuana

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Not long after in the US, Kenneth Endicott, the four-packs-a-day, chain-smoking chief of the National Cancer Institute, became convinced there had to be a safer way to smoke, and embarked one of the more bizarre chapters in the history of the war on cancer