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Non-invasive approaches include the detection of biological markers such as enzymes, antibodies, or specific proteins (e.g., lactoferrin, calprotectin, and C-reactive protein in bodily fluids that can be collected non-invasively, such as urine, fecal matter, or saliva (Hickman, 2024

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T-tests and chi-squared tests were conducted to evaluate the differences between groups for continuous and categorical variables, respectively (Tables 2 and 3)