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On the eighth day, the animals were exposed to the ETM three hours after cigarette smoke exposure in order to evaluate them under the influence of the substances present in regular cigarettes and tobacco-free cigarettes
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The study spanned various regions, including Western Europe, North America, Eastern Europe, the Middle East, Africa, South Asia, China, Southeast Asia, and South America, and classified countries based on income levels into high, upper-middle, and low-middle/low income
Logistic regression models were utilized to assess the association between EC use and the risk of respiratory symptoms and COPD using risk ratios along with their corresponding 95% confidence intervals