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14 Nortriptyline dosing recommendations for smoking cessation: 15, 17 Step 1 set a quit date Step 2 initiate nortriptyline 10 28 days before this quit date, initially at a dose of 25 mg daily Step 3 increase the dose gradually over ten days to five weeks to 75 100 mg Step 4 continue use for three months in total (can be continued for up to six months, if required) Doses should be slowly tapered when stopping nortriptyline to avoid withdrawal symptoms