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Our study indicates that cigarette smoke exposure inhibits cholesterol efflux in airway epithelial cells, leading to increased intracellular cholesterol levels, promoting ROS production, and the secretion of inflammatory factors, thereby exacerbating cigarette smoke-induced airway inflammation

With these new proposed cigarette health warnings, we have an enormous public health opportunity to fulfill our statutory mandate and increase the publics understanding of the full scope of serious negative health consequences of cigarette smoking, said acting FDA commissioner Ned Sharpless in a statement Thursday