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Your brain adjusts by reducing receptor sensitivity or changing the number of receptors available, explaining why long-term users experience less intense sensations than when they first started

Further detail is given in the Methods and Supplementary Sections S3.1 and S3.2

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Abstract Objective: To use the relation between cigarette consumption and cardiovascular disease to quantify the risk of coronary heart disease and stroke for light smoking (one to five cigarettes/day)