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Alteration of the normal epithelial-connective tissue architecture - the rete pegs may become "drop shaped"
The authors concluded that for uncomplicated depression in adults, it is unclear whether antidepressants are more efficacious than placebo . Similar reservations led physicians, researchers, patient representatives and politicians in the United Kingdom in 2023 to call for government commitment to reverse the increase of antidepressant prescribing to the general population
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