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Burdening legitimate operators with dramatically higher license fees is unfair and counterproductive because it raises costs for small retailers while doing nothing to stop the underground market that is already costing California an estimated $1.5 billion a year in lost tax revenue. Members help make our journalism possible

from UC Berkeley, also found that nicotine receptors in the reward pathway become desensitized by high doses of nicotine, which probably contributes to the negative experience of high doses

NEWS AND VIEWS Healthy cells in smokers lungs have a high burden of mutations, similar to the mutational profile of lung cancer

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