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AhR is a ligand-dependent transcription factor that participates in a whole range of biological processes including the metabolism of xenobiotics, cell differentiation, inflammation, melanogenesis and carcinogenesis 26

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While they make smoking more enjoyable, they can also mask the harshness of the smoke, potentially leading to deeper inhalation and increased exposure to harmful chemicals

Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors