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"Differences in Switching Away From Smoking Among Adult Smokers Using JUUL Products in Regions With Different Maximum Nicotine Concentrations: North America and the United Kingdom"

Of the 102 patients with undetermined aetiology, 31 (30%) developed overt vitamin B12 deficiency within 1 to 5 years of metformin use, 63 (62%) within 6 to 10 years, and 8 (8%) beyond 10 years, up to 30 years