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Anoop Misra, Diabetes Foundation (India), New Delhi, India, National Diabetes, Obesity and Cholesterol Foundation (N-DOC), New Delhi, India, Fortis C-DOC Centre for Excellence for Diabetes, Metabolic Disease, and Endocrinology, New Delhi, India

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With advancing age and disease duration, MS increasingly shifts toward a phenotype dominated by compartmentalized CNS inflammation, microglial activation, and neurodegeneration, while overt relapses become less frequent (55, 56)