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While rates have decreased by approximately two-thirds in the last 50 years, the Centers for Disease Control and Prevention reported in 2019 that 34.2 million Americans smoke cigarettes

Thus, there is a slight margin of error to consider

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Significant increases in genotoxicity or expression of proteins involved in mutagenesis were found following acute exposure to nicotine e-cigarette in 6 studies 28,34-37,42 , following short-to-medium term exposure in 1 study 33 , and following non-nicotine e-cigarette exposure in 1 study 25