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Pyrilamine is reported to be taken up from carrier-mediated transport with the involvement of H+/organic cation antiporter that drives H+ outward for its uptake, similar to that of nicotine, suggesting both molecules share a similar transport system for its uptake into the brain endothelial cells (Okura et al., 2008)

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Pregnant and breastfeeding women should probably be advised to either decrease, or where possible, cease cannabis use entirely