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Respiratory irritation and the bronchial constriction from a propylene glycol aerosol raise concerns about harm to people with asthma and chronic obstructive pulmonary disease, but one small study reports no harm but rather benefit when users quit smoking or smoke fewer cigarettes per day. Keep in mind, however, that the research here is still early, and this conclusion on e-cigarettes could change once tens of thousands of people and not just dozens or hundreds have been studied