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there is a high probability that one agent will out-compete or saturate the renal excretion mechanisms before the other co-administered agent(s) is/are eliminated

These mass concentrations agree with total particulate matter (TPM) measurements of fresh smoke collected on a filter directly downstream of the cigarette or joint (without dilution or aging due to sampling), which show smoking a marijuana joint produces roughly 3.4 (0.6) times more TPM than a tobacco cigarette following the same HCI routine with six puffs

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