How they get from that artful, lovely bent to the hunched-over grizzled townie is one of life's great mysteries
An alternative hypothesis is depicted on the right, in which inhalation of chemicals common in e-cigarette aerosols (propylene glycol, glycerin, nicotine, or THC) alters the inflammatory state of the lungs, including changing alveolar macrophages to a proinflammatory phenotype with the release of inflammatory cytokines (indicated by yellow circles), such that a second hit causes a pathologic inflammatory response
This classification encompasses e-cigarettes, e-liquids, vape pens, and other vaping materials
doi: 10.1016/j.amepre.2016.10.036 [DOI] [PMC free article] [PubMed] [Google Scholar] 13.Bozier J, Chivers EK, Chapman DG, Larcombe AN, Bastian NA, Masso-Silva JA, et al
Ultimately, pricing reflects a convergence of technological innovation, health priorities, and evolving nicotine consumption habits