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Mendelian randomization analysis revealed that smoking influenced gut microbiota composition, particularly Paraprevotella clara , which significantly mediated the association between smoking and type 2 diabetes

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Decreased leucine degradation through the reductive Stickland reactions could redirect leucine catabolism to the oxidative Stickland reactions explaining the significant increase of isovaleric acid in the supernatant of the sigL::erm mutant (Figure 8B) (Neumann-Schaal et al., 2015)

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