CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with Clozapine ODT and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3)]
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Just under two-thirds (60.9%) of the deaths attributable to ETS exposure occurred in non-smokers: 260 (95% CI 228297) in former smokers and 195 (95% CI 166224) in never-smokers