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Also, while nicotine is the most biologically active e-liquid constituent, the toxicological profile of inhaled nicotine is well characterized (99, 100), and its pharmacological effects are beyond the scope of this review

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Johns Wort and S-adenosyl-L-methionine.22 Other interventions No evidence on harms was identified for hypnotherapy, acupuncture, continuous auricular stimulation, laser therapy, or electrostimulation.22 E-cigarettes Fourteen RCTs27 31 , 33 , 34 , 36 , 37 , 39 , 45 48 and 1 cohort study49 provided data on e-cigarette harms, almost all at 36 months of follow-up