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Progress was initially notable at a state or national level, particularly the pioneering smoke-free public places legislation introduced in New York City in 2002 and the Republic of Ireland in 2004, and the UK efforts to encapsulate the crucial elements of tobacco control activity in the 2004 'six-strand approach' (to deliver upon the joined-up approach set out in the white paper 'Smoking Kills' [16] ) and its local equivalent, the 'seven hexagons of tobacco control'

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[3] Epidemiology [edit] The prevalence of oral leukoplakia varies around the world, but generally speaking it is not an uncommon condition

nicotine-pouch sales jumped 269% from January 2023 to December 2025, from $146.1 million to $539.5 million