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Health care professionals should inform users of these signs of toxicity.(20) Contraindications such as cardiovascular disease (e.g., recent myocardial infarction and unstable angina) and being pregnant or breastfeeding should be considered by health care professionals during treatment planning.(20) How to tailor the nicotine replacement dose for EC users The wide variety of ECs and liquid nicotine products available on the market has made it challenging for health care professionals to tailor the nicotine replacement dose