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Of all the included studies, only seven evaluated the effects of electronic cigarettes in a healthy non-tobacco smoking population, these studies revealed significant effects, including increases in heart rate, mean arterial blood pressure, arterial stiffness, and oxidative stress, as well as respiratory system changes such as alterations in the transcriptomes of the respiratory epithelium and alveolar macrophages, and a sudden increase in airflow resistance suggesting airway obstruction

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Reed later signed up for Schwartzs literature classes at Syracuse