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Syphilis infection progresses through four stages primary syphilis, secondary syphilis, latent syphilis, and tertiary syphilis stage

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doi: 10.1016/j.lungcan.2007.11.013 40

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Researchers have speculated that the accumulation of p62 and ubiquitinated proteins observed in the lung tissues of patients with severe COPD-emphysema suggests an insufficient autophagic clearance is involved in the pathogenesis of COPD (Tran et al., 2015)