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The painting reflects the artist's preoccupation with existential themes such as anxiety, identity, and mortality

Other research centers that received National Cancer Institute funds to study the impact of the graphic warning labels with different target populations include the Lung Cancer Disparities Center at Harvard University

However, it is simplistic to attribute the falling smoking rate solely to the rising price

Participants completed the Fagerstrm test for nicotine dependence (FTND) which asks questions such as: How soon after you wake up do you smoke your first cigarette? Do you find it difficult to refrain from smoking in places where it is forbidden? and How many cigarettes per day do you smoke? Scores for each answer were added up for a total score indicating a nicotine dependency of low (score 1-2), low to moderate (3-4), moderate (5-7) or high (8 or higher)

Despite these findings, the study emphasized that many included studies carried a high risk of bias, primarily because e-cigarette users often had a history of tobacco smoking