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A study of flight attendants [51] who cannot smoke during the flight showed that craving was related to the time remaining to the end of the flight more than to the length of abstinence (and presumably, of nicotine withdrawal)

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These early positive results have led to growing interest in cannabis as a potential treatment for concussions, with clinical trials ongoing

When taken to quit smoking, bupropion may confer both anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which mediates the reward pathways associated to nicotine use, and through the antagonism of the nicotinic acetylcholinergic receptor [30]