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For tobacco and marijuana smoke, respectively, 4350 and 2575 different compounds are detected, of which, 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause negative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms

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Many efforts have been made to fight the tobacco epidemic, including but not limited to marketing restrictions, increased taxation, media campaigns to promote cessation, and smoke-free air laws

Urinary cotinine as a major metabolite of nicotine that can be used as a short-term biomarker with half-life of only 18h, which is reported to have a strong correlation with self-reported exposure to tobacco smoke 17

respiratory infections