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The most effective way to reduce nicotine levels in the body is to quit smoking or cease nicotine product use, allowing the body's natural processes to gradually eliminate nicotine and its metabolites over time

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A deeper understanding of these individuals and networks (criminal histories, motives, ties to organized crime, financing mechanisms, links to adjacent markets, etc.) would provide valuable knowledge about the supply chain and illicit procurement paths and the ways in which they may evolve in the future

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By the end of the study period, 22.4% had quit and were still alive, 18.6% had quit before they died, 39.6% had died with no report of quitting before death, and 19.4% were alive and still smoking by the end of the follow-up period (Fig