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As previously mentioned, nicotine is a recognized addictive constituent of cigarette smoke, addiction to it is likely to spread to other, riskier components

According to the Food and Drug Administration (FDA), a product can contain as little as 50% synthetic nicotine and still be labeled as synthetic. Manufacturers say the tobacco-derived nicotine used in their products is purified or synthetic, but purifying nicotine derived from tobacco enough to reach medicinal levels is expensive

In females, current smokers had higher serum uric acid levels than never smokers, and both hyperuricemia and gout were significantly more frequent in current smokers than in never smokers