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30 SD rats were randomly divided into 5 groups (6 rats/ group): control group, COPD model group, AZI low-dose (25 mg/kg) group, AZI middle-dose (50 mg/kg) group and AZI high-dose (100 mg/kg) group

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The comparative efficacy test has created an insurmountable barrier to placing lawful, regulated flavored products on the market and, as a result, has created a substantial opportunity for illicit trade without any compensating benefits

Macdonald said she would be "shocked" if Rothmans Benson & Hedges do not request leave to appeal