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Macrophages regulate epithelial and stromal cell function by secreting enzymes and inflammatory factors that act directly and indirectly on airway structural cells, such as IL-1, TNF-, IL-8, monocyte chemoattractant protein-1(MCP-1), reactive oxygen species (ROS) and MMPs, directly involved in the process of airway remodelling 60,61

However, in March of 2020, Prince Edward Island changed the age to 21 from 19, with exemptions for those who were already old enough to buy such products