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NRTs increase the rate of quitting by 50% to 60%, regardless of setting [footnote 50] combination NRT is more effective with regard to long term quit rates than a single form of NRT in adults who are motivated to quit [footnote 43] higher dose (21mg/24-hour) nicotine patches result in higher quit rates than lower dose (14mg/24-hour) nicotine patches in those motivated to stop smoking [footnote 43] there is no evidence of a difference between fast-acting NRT, such as gum and lozenge, and nicotine patches in those motivated to stop smoking (based on high quality evidence) [footnote 43] varenicline may be more effective than bupropion with regard to quit rate and relapse [footnote 41] varenicline improves abstinence compared with bupropion or NRT, however it is more likely than placebo to lead to nausea, insomnia, abnormal dreams, headaches and serious adverse events

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