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33 Through this cascade of structural remodeling, Parkin transforms from a selfinhibiting dormant enzyme to an active E3 to ubiquitinate a number of OMM proteins, such as mitofusins1 (MFN1), 34 mitofusins2 (MFN2), 34 mitochondrial Rho-GTPase 1 (Miro1), 35 and voltage-dependent anion channel 1 (VDAC1)