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In most cases, the elimination of nicotine in mammals is via conversion to cotinine by C-oxidation

Furthermore, increasing VTA DA neuron firing mimicked the effects of chronic nicotine exposure on decision-making measures, linking the behavioral alterations with the physiological changes to DA neurons we observed in nicotine-treated mice

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Burning is usually felt first, but it is soon followed by the unbearable itch, which can, for some women, be thought of as burning fire upon their very existence