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Symptoms of smokers flu include: Coughing Sore throat Sneezing Chest tightness Body aches Headache Fatigue Smokers flu can occur on its own, but it is more likely to accompany classic physical and mental symptoms of nicotine withdrawal, including: Slowed heart rate Upset stomach Constipation Gas and bloating Diarrhea Increased hunger Anxiety Depression Apathy or general unhappiness Irritability Difficulty concentrating Nicotine craving One study showed that 61.1% of smokers who quit experience symptoms of nicotine withdrawal when they stop