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Acetaldehyde was shown to alter cellular respiration in cultured microvascular endothelial hBMVEC cells, which mainly comprise the bloodbrain-barrier, thereby suggesting negative effects on bloodbrain-barrier integrity (121).Further, in cultured primary cortical neurons, acetaldehyde impaired mitochondrial respiration via NOX -mediated activation (122), and in brain mitochondria in vitro , acrolein inhibited mitochondrial respiration via complex I (123)

In 2017, 5.5 percent of high school students smoked on at least one day in the past 30 days

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Public education: Research has consistently demonstrated that tobacco-related public education campaigns save lives, promote quit attempts, reduce youth smoking initiation, lower health costs and blunt the impact of tobacco industry marketing