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Denlinger-Apte, Ph.D., M.P.H., from the Wake Forest University School of Medicine in Winston-Salem, North Carolina, and colleagues examined whether people who smoke may increase their smoking to compensate for the reduced nicotine levels when smoking VLNCs for prolonged periods

While there is some evidence to suggest that both these methods are less harmful than traditional cigarettes, there are some key differences between the two

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Methylation at AHRR acts as marker for tobacco exposure The authors noted that AHRR methylation could serve as a molecular marker for tobacco-related harm

Their special design minimizes smoke exit and water entry