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In a recent study, human blood neutrophils were stimulated with phorbol ester (PMA for phorbol-12-myristate-13-acetate, a compound known for its ability to stimulate NETosis) in the presence or absence of cigarette smoke condensate (CSC)

It is strongly associated with the development and progression of hepatic steatosis, increased oxidative stress, mitochondrial dysfunction, activation of pro-inflammatory and pro-fibrotic pathways, and systemic metabolic dysregulation

The exceptions were child and adult health-related quality of life measures, and the HIEC and HEIC sub-scores