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Nevertheless, both intravenous and vapor nicotine self-administration paradigms are valuable tools to investigate various aspects of nicotine dependence, and established protocols demonstrate blood levels of nicotines metabolites, cotinine, 5-hydroxycotinine and cotinine N-oxide, similar to that found in human smokers (60, 62, 65, 7274)

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In May 2017, one manufacturer submitted a Modified Risk Tobacco Product Application (MRTPA) for his HTP (88) and in January 2018, the Tobacco Product Scientific Advisory Committee (TPSAC) met to give a recommendation

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