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Prolonged exposure resulted in a change in OSCC morphology from polygonal to elongated, a decrease in the levels of the epithelial marker Cytokeratin-13 and an increase of mesenchymal markers (N-cadherin and -Smooth Muscle Acton (SMA)), indicating an Epithelial-to-Mesemchymal Transition (EMT) phenotype [121]

A smoker may notice these symptoms as part of the recovery process

Orthodontic Treatment In some cases, correcting misaligned teeth with braces or clear aligners can help redistribute biting forces more evenly, which may reduce gum recession caused by abnormal pressure

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Furthermore, the authors concluded that these effective smoking cessation therapies should be made more widely available than they currently are