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This can lead to increased dryness, loss of elasticity, and reduced ability to regenerate healthy cells

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Pleural Mesothelioma Prevalence: 70% to 79% of all cases Location: Pleura (tissue around lungs and chest wall) Treatments: Immunotherapy, surgery, chemotherapy 5-year survival rate: 7% to 22%, according to the American Cancer Society Peritoneal Mesothelioma Prevalence: 10% to 30% of all cases, second most common type Location: Peritoneum (abdominal cavity lining) Treatments: HIPEC surgery is highly effective for this type 5-year survival rate: 65% (significantly better than pleural) Pericardial Mesothelioma Prevalence: About 1% of cases (very rare) Location: Pericardium (sac around the heart) Median survival: 2 to 6 months Treatment challenges: Limited options because of heart proximity Testicular Mesothelioma Prevalence: Less than 1% of cases, rarest form Location: Tunica vaginalis (membrane around testes) Common symptom: Testicular mass or swelling Prognosis: Better than other types, 33% of patients live 10+ years Mesothelioma can spread from one location to another as it progresses

The change of epithelial cells-derived EVs exposure to CS The oral mucosa is the first line that encounters with CS, which makes the epithelial cells in oral cavity are inevitably as the first type of cells affected by CS

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