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Due to the characteristic expression of Ccl2/Ccl7 by murine MoAM, we hypothesize that small sputum macrophages reflect their human orthologs and correspond to the human CCL2 + mono-like macrophages that were increased in BALF of the emphysematous COPD patients

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They have also noted that paternal smoking is associated with an increased incidence of birth defects and disease in the child