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As a reactive a,b-unsaturated aldehyde, acrolein can exacerbate dyslipidemia that can lead to accelerated atherosclerosis, modify A-I protein in high-density lipoprotein (HDL) [33, 34] and catalytic neutrophil-mediated inflammation [35], and enhance platelet activation which contributes to an increased risk of thrombosis in animal models [36]

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For the study, 30 dependent cigarette smokers came into the lab after smoking normally or abstaining for 12 hours from smoking, and were given pills of either CBD or a placebo, on separate occasions

This safety profile makes CBD appropriate for long-term therapeutic use