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Overall, smokers are at least three times more likely than non-smokers to develop bladder cancer

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Table 2: 2023 Burley Prices per Grade: Top 6 Buyers Changes in dark tobacco contract volumes for 2023 varied considerably among companies, but overall were down significantly amidst a changing smokeless tobacco product market

Based on a power calculation using the Clincalc.com (ClinCalc LLC, Arlington Heights, IL, USA) sample size calculator with an assumed average BP of 120 mmHg, a BP variability of 5 mmHg, a clinically relevant difference of 6 mmHg, an enrollment ratio of 3, an alpha of 0.05, and a power of 80%, at least 28 participants, of which at least 7 in each of the cessation and relapse groups, were to be included