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Because of the difficulty in determining the directionality of associations between e-cigarette and combustible tobacco cigarette use in cross-sectional studies and the presence of a sufficient number of high-quality longitudinal studies, literature review was limited to original primary reports and reviews of studies with a longitudinal design that had a minimum follow-up period of 6 months (i.e., a period in which meaningful changes in youth tobacco use has been demonstrated in prior work)

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Differential expression of biomarkers in lung adenocarcinoma: a comparative study between smokers and never-smokers