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Nicotine is one of the most addictive drugs around, which is why an infamous 1988 report on addiction released by the Surgeon General even went as far as to compare a nicotine addiction to heroin addiction

The "Liqun" brand was initially established in 1960

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Nat Rev Cancer 13:258271 Ben Q, An W, Sun Y, Qian A, Liu J, Zou D, Yuan Y (2020a) A nicotine-induced positive feedback loop between HIF1A and YAP1 contributes to epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma