Epidemiology Bimodal age distribution: 1530 yrs and 5070 yrs Slight male predominance Higher prevalence in urban populations Etiology & Pathogenesis Multifactorial: genetic predisposition + immune dysregulation + environmental triggers Inflammation limited to mucosa and submucosa Begins in the rectum extends proximally (continuous lesions) Clinical Features Intestinal: Bloody diarrhea Mucus in stool Tenesmus Urgency Abdominal pain (LLQ) Systemic: Fatigue Weight loss Fever (severe disease) Extra-intestinal Manifestations Musculoskeletal: Peripheral arthritis, sacroiliitis Skin: Erythema nodosum, pyoderma gangrenosum Eyes: Uveitis, episcleritis Hepatobiliary: Primary sclerosing cholangitis (PSC) Extent (Montreal classification simplified) Proctitis rectum only Left-sided colitis up to splenic flexure Pancolitis entire colon Diagnosis Colonoscopy with biopsy gold standard Continuous erythema, friability, ulceration Histology: Crypt abscesses, mucosal inflammation Labs: ESR/CRP, anemia Exclude infection (stool cultures, C
Reviewed 17 September 2013 "The impact of electronic cigarettes on the paediatric population"
Their "Tube Cut" technology makes them exceptionally compatible with electric injectors, while the 1000ct bulk value offers a significant cost advantage
"Billboard Indonesia Songs Week of March 5, 2022"
Pick a large, sturdy pumpkin and carve generous eye and mouth cutouts so smoke escapes freely, then remove any candle or light from inside
