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This directive necessitated pre-market notifications for all e-cigarette devices and e-liquids

This is a retail policy helping to enforce the sale of age-restricted products such as tobacco, whereby retailers need to check for proof of age for those who may look 25 years old and under

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They reported an improvement in FEV1, performance in the methacholine challenge test, and asthma control questionnaire but no change in asthma exacerbations when these subjects were followed prospectively over a 12-month period (Polosa et al., 2014a, 2016a)