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Whilst the hippocampus projects directly to these regions [78,79,80], it is not possible to determine whether reductions in rCBF here are due to primary drug effects (i.e., due to local increases in GABAergic inhibition), or secondary, downstream effects deriving from drug-induced reductions in hippocampal hyperactivity

Cancer 131 , 12101219 (2012)

Tobacco weight: 20g Nicotine level: 43mg/g

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The nicotine itself reduces blood flow, affecting teeth and gums, potentially causing gum recession and death of gum tissue